DAN JONES, PH.D.DEPT. OF BIOLOGY
Dr. Jones has led 33 students over the past 6 years on a research project focused on understanding cell-regulatory cascades in bone and cartilage cells. 15 of these students (Brittany Mead, Heather Morgan, Alyssa Mann, Laura Tedeschi, Chris Sloan, Spencer Lang, Cory Hines, Megan Gragg, Jonathan Stofer, Kaitlin Reimann, Tyler Derr, Emily Heller, David Collins, Paul Landis, and Nathan Linna) are co-authors on a manuscript now published in the Journal of Cellular Biochemistry entitled, “Reveromycin A-Induced Apoptosis in Osteoclasts is Not Accompanied by Necrosis.” (accepted January 2015)
Meaning in layman's terms: A naturally occurring antibiotic, reveromycin A, shows promise as an osteoporosis therapeutic in that it causes death specific to bone-resorbing cells. Further, the death that is induced by reveromycin A in bone-resorbing cells is not the type of cell death that causes inflammation of the surrounding bone tissue.